O-004 The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of good functional outcome in stroke patients with intracranial large vessel occlusion
Bibliographic record
Abstract
Background and purpose The role of non-invasive methods in the evaluation of collateral circulation has yet to be defined. We hypothesized that a favorable pattern of leptomeningeal collaterals, as identified by CT angiography (CTA), correlates with improved outcomes. Methods Data from a prospective cohort study at two university based hospitals where CTA was systematically performed in the acute phase of ischemic stroke were analyzed. Patients with complete occlusion of the intracranial internal carotid artery and/or the middle cerebral artery (segments M1 or M2) were selected. Leptomeningeal collateral pattern was graded as a three category ordinal variable (less, equal or greater compared with the unaffected contralateral hemisphere). Univariate and multivariate analyses were performed in order to define the independent predictors of good outcome at 6 months (modified Rankin Score (mRS) ≤2). Results 196 patients were selected. Mean age was 69±17 years and median National Institutes of Health Stroke Scale (NIHSS) score was 13 (IQR 6–17). In the univariate analysis, age, baseline NIHSS, pre-stroke mRS, Alberta Stroke Programme Early CT Score, admission blood glucose, history of hypertension, coronary artery disease, congestive heart failure, atrial fibrillation, site of occlusion and collateral pattern were predictors of outcome. In the multivariate analysis, age (OR 0.95; 95% CI (0.93–0.98); p=0.001), baseline NIHSS (OR 0.75; 0.69–0.83; p<0.001), pre-stroke mRS (OR 0.41; 0.22–0.76; p=0.01), intravenous recombinant tissue plasminogen activator (OR 4.92; 1.83–13.25; p=0.01) and leptomeningeal collaterals (OR 1.93; 1.06–3.34; p=0.03) were identified as independent predictors of good outcome. Abstract O-004 Figure 1 Examples of robust and poor leptomeningeal collaterals. (A) Good leptomeningeal collaterals: 51-year-old male, initial National Institutes of Health Stroke Scale (NIHSS) of 12, modified Rankin score at 6 months: 1. (B) Poor leptomeningeal collaterals: 47-year-old female, initial NIHSS of 13, modified Rankin score at 6 months: 6. Arrows point to the site of occlusion at the middle cerebral artery (MCA)–M1. The strength of leptomeningeal collaterals is estimated by the degree of distal reconstitution of the MCA vessels. Conclusion Consistent with angiographic studies, leptomeningeal collaterals on CTA are also a reliable marker for good outcome in acute ischemic stroke patients presenting with large vessel occlusion. The acquisition of this information does not require any extra time or processing and may greatly assist in the selection of patients who are potential candidates for endovascular treatment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".