PO-23 DEPENDENCY OF ARTERIAL STIFFNESS INDICATORS ON ACUTE BLOOD VOLUME CHANGES
Bibliographic record
Abstract
the differences in markers of vascular function between Hispanics (HS), Caucasians (CA), and African Americans (AA).This study sought to assess the differences in vascular function at the endothelial cell level between these racial groups.Methods: Three human umbilical vein endothelial cell (HUVEC) lines from different donors with HS, CC, and AA backgrounds were used.All cells were grown until confluent before cell medium and cell lysate was harvested.The cell medium was collected for the measurement of Interleukin 6 (IL-6) in an ELISA assay kit.The harvested cell lysate was used for western blotting for the measurement of Endothelial Nitric Oxide Synthase (eNOS), Phosphorylated Endothelial Nitric Oxide Synthase (p-eNOS), and Endothelin Converting Enzyme (ECE).Results: The expression of eNOS in both the CC and HS cell lines was significantly lower when compared to the AA cell lines (p 0.001).p-eNOS expression was significantly higher in the HS cell lines compared to both the AA and the CA cell lines (p 0.001).The p-eNOS to eNOS ratio was significantly lower in both the AA (p 0.03) and CA (p 0.001) cell lines compared to the HS cell lines.ECE expression was significantly higher in the HS cell lines compared to the AA cell lines (p 0.001).IL-6 levels were significantly higher in the CA and HS cell lines compared to the AA cell lines (p 0.001).Conclusions: Differences in endothelial cell biology that could affect function were evident among cell lines of different racial origin.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".