Bibliographic record
Abstract
Microsporidia are eukaryotic intracellular parasites that evolved from fungi. However, they are highly derived and specialized, and lack several typical eukaryotic features, such as canonical mitochondria, flagella and peroxisomes. They also exhibit seemingly “primitive” traits, probably due to their extreme sequence divergence and reductive evolution, which long obscured their true phylogenetic affinity. Gene content and genomic architecture in Microsporidia are known from E. cuniculi, the only species whose complete genome has been sequenced. A genomic sequence survey of A. locustae, a second and distantly related species, carried out in our laboratory provided valuable data for many studies that improved our knowledge on the biology and evolution of Microsporidia. We present here the latest results of our survey, emphasizing comparative analyses between A. locustae and E. cuniculi in order to explore the dynamics of genome evolution and compaction in this intriguing group of parasites. We found that, in spite of their extreme rates of sequence evolution, microsporidian genome structure evolves slowly compared to other eukaryotic groups and we propose that it is a consequence of compaction. We also report the discovery and characterization of a photolyase in A. locustae that protects the spore from DNA damage. In addition, comparative analysis allows the identification of several important genes that would otherwise not be recognised due to the extreme level of sequence evolution. Finally, we compared intergenic DNA between both species aiming to understand the structure of regulatory sequences in these highly compacted genomes.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".