Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Hexokinase1 (HXK1) is an evolutionarily conserved glucose sensor in plants. However, the molecular mechanism through which HXK1 controls the expression of genes encoding proteins involved in photosynthesis is a mystery. Recent research demonstrates that a previously unknown HXK1 nuclear complex controls the expression of specific photosynthetic genes, a process that is independent of glucose metabolism but requires two unexpected partners, VHA-B1 and RPT5B. Both VHA-B1 and RPT5B have well-established and conserved functions in processes that are seemingly unrelated to glucose-dependent regulation of gene expression, and neither of them is a predominantly nuclear protein. Biochemical, genetic, and molecular evidence demonstrates that VHA-B1 and RPT5B directly interact with HXK1 in the nucleus and that the HXK1 complex binds to the cis-acting elements of chlorophyll a/b binding protein 2, a photosynthetic gene that is transcriptionally suppressed by glucose. The identification of the HXK1 nuclear complex reveals an unexpected glucose-signaling mechanism and reinforces the notion that metabolic enzymes can play unique roles in signal transduction by directly controlling gene expression in the nucleus.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it