Bibliographic record
Abstract
3-MONTH-OLD FEmale infant was referred to the ophthalmology unit as partoftheinvestigationforinfantilespasms.Ocularexaminationshowednormalvisualattentiveness and pupillary function. Theopticnerveswereverticallyoval and there were multiple chorioretinal lacunae adjacent to the discs (Figure 1). Neuroimages revealed absence of the corpus callosum. Aicardisyndromewasdiagnosed.By the age of 6 years devastating neurological deterioration had occurred. Reexamination of the retinas at this time revealed increased pigmentation of the retinal lesions, even within the lacunae (Figure 2). COMMENT In 1965 Aicardi and associates 1 describedasyndromeconsistingofcallosal agenesis, chorioretinal lacunae,andinfantilespasms.Sincethen many cases of this X-linked recessivedisorderhavebeenreportedand the spectrum of ophthalmological and neurological findings is now broad. Becausethechorioretinallacunae are characteristic, their recognition is critical. Aicardi et al 1 first described these lesions as areas of “pseudotoxoplasmic”atrophicchoroiditis. They may vary in size from 0.1toseveraldiscdiametersandtend toclusteraroundtheopticnerve 2 or even involve it. The so-called colobomas of the optic nerves do not resemble the fusion defect that results in true colobomas. Although the lacunae of Aicardi syndrome have been likened to the pigmentary changes associated with infectious chorioretinopathies, 3 they really in no way resemble the harsh
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".