Histocompatibility analysis of clonal diversity in unisexual hybrids of the killifishes<i>Fundulus heteroclitus</i>and<i>Fundulus diaphanus</i>
Bibliographic record
Abstract
Hybrids of the killifishes Fundulus diaphanus and Fundulus heteroclitus, found at two sites on the Atlantic coast of Nova Scotia, are unisexual diploid gynogens. Because there seemed to be many opportunities for the sexual progenitor species to hybridize and form new clones at these sites, we initially had expected that clonal diversity might be high among the hybrids. However, examination of their histocompatibility genomes, via inter-individual scale grafting, provides evidence, albeit not conclusive, that most of the hybrids at the two sites, which are separated by 125 km, comprise a single clone. Grafts made among F. diaphanus were rejected within an average of 16-20 days, establishing that sufficient diversity exists within the histocompatibility genomes of these fish to permit their immune systems to reject foreign melanophores. Grafts made from F. diaphanus to the hybrids were also rejected, within an average of 17-26 days, demonstrating that the hybrids possessed competent immune systems. Grafts made between hybrids were nearly always accepted. Those few that appeared to be rejected were usually accepted when regrafted. Melanophores carried on the graft remained visible for the duration of the study (90-180 days) or, if they slowly disappeared, they did so at a rate comparable with that of autograft scales.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".