Olfactory learning in the rat pup: A model that may permit visualization of a mammalian memory trace
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Over the past 10 years considerable insight into intracellular interactions leading to long-term memory formation have been gleaned from various neural circuits within invertebrate and vertebrate species. This review suggests that, while certain intracellular signaling pathways are commonly involved across species, it is important to analyze specific neural systems because critical differences among systems appear to exist. The olfactory bulb has been used by our group to estimate the influence of neuromodulatory systems (serotonin and norepinephrine) on intracellular processes leading to learning. We describe here how activation of noradrenergic input to mitral cells increases cAMP leading to CREB phosphorylation when paired with a conditioning stimulus, odor. CREB phosphorylation is causal in odor preference learning leading to long-term memory for the odor. However, the relationship between cAMP activation and CREB phosphorylation is not straight forward; overstimulation of cAMP pathways impedes learning and prevents CREB phosphorylation. Excessive CREB phosphorylation also interferes with learning.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it