Potentiation between Pentagastrin and Bethanechol Chloride in Stimulation of Gastric Secretion from Isolated ex vivo Canine Stomach Perfused with Homologous Blood
Bibliographic record
Abstract
The totally isolated canine stomach, perfused with homologous blood, is able to secrete juice rich in H+ for several hours. This ex vivo preparation was used for the study of secretion stimulated by pentagastrin and/or bethanechol chloride, a stable cholinergic drug. Combinations of pentagastrin plus bethanechol used in this study gave significantly higher outputs of HC1 and pepsin than could be accounted for on the basis of summation of stimulatory effects. True potentiation with regard to acid and pepsin secretion was evident when the cholinergic drug was superimposed on pentagastrin stimulation. It was concluded that potentiation between bethanechol chloride and pentagastrin occurs in the stimulation of secretion from the totally isolated canine stomach perfused by homologous blood. We also studied mechanical activity and myoelectrical activity of isolated stomachs. These activities varied with the changes in stimulation. The mechanical activity markedly increased when cholinergic drug was added to pentagastrin stimulation. Bethanechol chloride appeared to be a very potent stimulant of mechanical activity of the isolated stomach.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".