MEMORANDUM FOR: Science Writers and Editors on the Journal Press List: DNA Repair Pathway Found To Be Involved in Resistance to Chemotherapy Drug
Bibliographic record
Abstract
September 27, 2001 (EMBARGOED FOR RELEASE 4 P.M. EDT October 2) A new study has found that a common DNA repair mechanism plays a role in resistance to the chemotherapy drug melphalan. The results suggest that interfering with this repair process may sensitize cancer cells to melphalan treatment, conclude Zhi-Min Wang, Lawrence C. Panasci, M.D., and colleagues from the Lady Davis Institute for Medical Research at McGill University’s Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Canada. Their research appears in the Oct. 3 issue of the Journal of the National Cancer Institute. Melphalan is in a group of drugs called nitrogen mustards, which are alkylating agents. The drug is used to treat some breast cancers and ovarian cancers. Melphalan treatment results in toxic DNA damage—interstrand cross-links and double-strand breaks—which leads to cell cycle arrest and cell death. Certain DNA repair mechanisms will reverse this damage, which may make the cells resistant to the therapy. There are two major pathways involved in repairing these types of damage—homologous recombinational repair, in which the undamaged sister chromatid is used to repair the DNA, and nonhomologous DNA endjoining (NHEJ), in which proteins simply fuse together ends of damaged DNA.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.012 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.005 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.006 | 0.006 |
| Insufficient payload (model declined to judge) | 0.112 | 0.090 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".