A DIETARY PHASE 2 ENZYME INDUCER IN ANIMAL MODEL OF ESSENTIAL HYPERTENSION: PP.29.158
Bibliographic record
Abstract
Numerous studies have demonstrated the health benefits of fruits, vegetables, spices and herbs. For instance, consuming a clove of garlic (or equivalent) decreases cholesterol levels and attenuates hypertension. Previous studies in our laboratory have shown that broccoli sprouts rich in glucoraphanin, a precursor of a potent phase 2 protein inducing isothiocyanate sulforaphane, decreases oxidative stress and ameliorates hypertension. The question this study addressed was the importance of a food matrix in causing these beneficial effects, i.e., can one see the same effects by administration of sulforaphane alone? Sulforaphane (5, 10 and 20 μMoles/Kg) was administered by daily gavage to 5-wk old Spontaneously Hypertensive Stroke Prone rats (SHRsp) for 4 months. Blood pressure was measured weekly by tail cuff and at the end of the experiment by an external catheter inserted into the carotid artery in anesthetized animals. For comparison, age-matched normotensive Sprague Dawley (SD) rats were treated in the same manner. SHRsp control rats had significantly higher Systolic Blood Pressure (SBP) (179.9 ± 4.3 mm Hg) than control SD rats (83.98 ± 1.69). Sulforaphane treatment significantly lowered SHRsp blood pressure to 157.7 ± .21. There was no effect of sulforaphane treatment on SD rat SBP (93.9 ± 4.26). We conclude that the health benefit previously demonstrated in our laboratory is due to sulforaphane.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".