LONG-TERM CIRCULATORY SUPPORT OUTSIDE OF THE HOSPITAL
Bibliographic record
Abstract
Purpose: Ventricular assist devices (VADS) are increasingly being utilized outside of the hospital setting. This application places additional and more stringent demands on device design and functionality. A fully implantable VAD (i.e. one that functions without the need for percutaneous leads and vents) has been developed. Methods: A major issue with long-term use of VADs outside of the hospital setting, is patient acceptability and quality of life. To address this issue, the HeartSaver VAD development program focused on 2 areas: 1) Implantability, and 2) Recipient Quality of Life Post-Implant. To improve implantability, the device is designed to be implanted in the thoracic cavity (via median sternotomy). The device will be anchored to the rib cage to eliminate device dislodgement. To improve recipient lifestyle, the device will be remotely monitored and controlled, freeing the patient from the need to frequently visit the hospital and allowing greater peace of mind for the recipient. The device utilizes remote power transfer and an internally implanted battery allows the recipient to indulge in a wide range of normal lifestyle activities (bathing, swimming, showering, changing clothes, etc.), unencumbered by any external components, further enhancing quality of life and freedom of movement. Results: The first prototype of the device has been operating on the bench for over 7 years failure free. Three series of in vivo studies (N=43) in bovine, for up to 30 days of support, have been conducted, demonstrating: 1) device implantability, 2) performance & ability to sustain circulation, and 3) remote monitoring and control capabilities. Studies to date, have demonstrated acceptable implantability and performance of the developed device. Based on these studies, a refined version of the device (pre-clinical version) was developed and manufactured. In vitro and in vivo studies of this pre-clinical version of the device are currently underway in preparation for clinical trials.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.009 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".