Hippocampal-Prefrontal Cortical Circuit Mediates Inhibitory Response Control in the Rat
Bibliographic record
Abstract
We investigated the interdependent function of the ventral hippocampus (vHC) and ventral prefrontal cortex (vPFC) in visuospatial attention and inhibitory control using a disconnection lesion approach. Rats were trained, and several aspects of their cognitive performance tested on the 5-choice reaction time task. The animals were prepared with unilateral lesions of both the vPFC and vHC, either in the same hemisphere ("ipsilateral") or in opposite hemispheres ("disconnection"). The disconnection lesion led to both impulsive and compulsive behavior. This deficit is reminiscent of the effects of either bilateral vPFC or bilateral vHC lesions on the same task and is thought to reflect the bihemispheric disruption of the hippocampal-prefrontal circuit. With ipsilateral lesions, behavioral deficits were transient or absent altogether, suggesting that the intact hemisphere was able to exert near normal levels of behavioral control. These behavioral effects were observed in the absence of any changes to visual attention, speed of response, or general motivation. This study provides evidence that optimal inhibitory control of behavior draws upon the functional interaction between the vHC and vPFC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".