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Record W2015530630 · doi:10.1186/s13059-014-0462-7

Toward better benchmarking: challenge-based methods assessment in cancer genomics

2014· article· en· W2015530630 on OpenAlexafffund
Paul C. Boutros, Joshua M. Stuart, Andrea Califano, Gustavo Stolovitzky

Bibliographic record

VenueGenome biology · 2014
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsCanada Research ChairsUniversity of TorontoOntario Institute for Cancer Research
FundersNational Human Genome Research InstituteNatural Sciences and Engineering Research Council of CanadaProstate Cancer CanadaGovernment of OntarioCanadian Institutes of Health ResearchGenome CanadaNational Cancer InstituteNational Institutes of HealthOntario Institute for Cancer ResearchMovember Foundation
KeywordsBenchmarkingGenomicsData scienceBiologyHuman geneticsCrowd sourcingGenome BiologyComputational biologyComputer scienceGenomeGeneticsBusinessGene

Abstract

fetched live from OpenAlex

Rapid technological development has created an urgent need for improved evaluation of algorithms for the analysis of cancer genomics data. We outline how challenge-based assessment may help fill this gap by leveraging crowd-sourcing to distribute effort and reduce bias.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.163
metaresearch head score (Gemma)0.309
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.837
Threshold uncertainty score0.862

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1630.309
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0070.005
Science and technology studies0.0030.004
Scholarly communication0.0100.008
Open science0.0040.012
Research integrity0.0050.005
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.347
Teacher spread0.315 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designSimulation or modeling
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations45
Published2014
Admission routes2
Has abstractyes

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