Cholestasis in Newborn
Bibliographic record
Abstract
Cytomegalovirus (CMV) is one of the most important intrauterine infections that cause birth defects in humans with hematogenous transmission rate of 0.5% to 2.5%, on average. The early transmission of infection from mother to fetus decreases the prognosis and increases the chances of serious anomalies. The objective of this case report is to instruct the neonatologist that despite the rarity of neonatal cholestasis, this may be a case of intrahepatic cholestasis resulting from congenital cytomegalovirus infection. This study aims to report the case of a 28 weeks and 6 days old child, presenting 1080 g birth weight, Apgar score 5 and 8, untreated sepsis, thrombocytopenia, leukocytosis, and jaundice with predominance in the evolution of direct bilirubin. To find out the cause of jaundice, serum bilirubin levels, serology and PCR (polymerase chain reaction) were performed for cytomegalovirus. Serology for cytomegalovirus was negative in spite of the molecular analysis by PCR in urine samples having demonstrated consistent results with the identification of genomic sequences of cytomegalovirus. Bilirubin values were: Total 15.58 mg%; Direct 12.36 mg%. It was concluded that treatment with ganciclovir resulted in satisfactory clinical response to treatment of cholestatic jaundice source cytomegalovirus. doi: http://dx.doi.org/10.4021/jmc1320w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".