Oral vinorelbine: a Better Choice for Concurrent Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer
Bibliographic record
Abstract
Background: Lung cancer is the most common cancer in the world, and causes 1.3 million deaths annually. Approximately 45% of patients diagnosed with non-small cell lung cancer (NSCLC) have locally advanced stage III disease. Standard treatment is concurrent chemoradiotherapy (CCRT) with two drugs, but severe toxicities are common. Several single-agent CCRTs have been developed to overcome this problem. Methods: We reviewed the records of 24 patients with stage III NSCLC who received single-agent vinorelbine CCRT at the National Cheng Kung University Hospital from January 1, 2005 to May 31, 2009. Nine patients received with vinorelbine intravenous infusion (15 mg/m 2 /week) and fifteen with oral vinorelbine 40mg/m 2 /week. Thoracic radiation was given over 6 weeks in 1.8 Gy/day fractions (total median dose of 59.7 Gy). The primary endpoint was the evaluation of time to progression (TTP) of these patients. The secondary endpoints were analysis of therapy-related toxicities and overall response rate. Results: Median age was 70 years (range: 58-81 years), and median follow-up time was 430 days (range: 101-1363 days). Eighteen patients were male, six were female and the median ECOG grade was 1. Vinorelbine was given for a median of 5.5 weeks (range: 4-8 weeks). All patients completed all planned cycles of CCRT. Seven patients (29.2%) had radiation pneumonitis. No patient had a complete response, and thirteen patients (54.2%) had a partial response. The median time to progression (TTP) was 6.4 months (95% confidence interval: 4-8.7 months), the median survival time was 24 months (95% CI: 13.8-34.9 months), and the 1- and 2-year survival rates were 68.5% and 41.1%, respectively. Conclusion: Treatment of stage III NSCLC patients with single-agent vinorelbine CCRT had a better median survival time and 2-year survival rates with fewer toxicities when compared with other therapies. Oral vinorelbine with its convenience in administration is an ideal choice for CCRT.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".