Hypothalamic resistin induces hepatic insulin resistance
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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
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all 1,000 screened works →All three models called this out of scope.
Physiology study of hypothalamic resistin and hepatic insulin resistance; the object is a metabolic mechanism.
The study investigates hypothalamic resistin and insulin resistance, not research practice.
Physiology study of hypothalamic resistin and insulin resistance; biomedical domain.
Abstract
Circulating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expression in the liver. The infusion of either resistin or an active cysteine mutant in the third cerebral ventricle (icv) or in the mediobasal hypothalamus stimulated GP independent of changes in circulating levels of glucoregulatory hormones. Conversely, central antagonism of resistin action markedly diminished the ability of circulating resistin to enhance GP. We also report that centrally mediated mechanisms partially control resistin-induced expression of TNF-alpha, IL-6, and SOCS-3 in the liver. These results unveil what we believe to be a novel site of action of resistin on GP and inflammation and suggest that hypothalamic resistin action can contribute to hyperglycemia in type 2 diabetes mellitus.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Journal of Clinical Investigation
- Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Field
- Medicine
- Canadian institutions
- University Health Network
- Funders
- National Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteUniversity of TorontoNational Institutes of HealthAmerican Diabetes Association
- Keywords
- ResistinInternal medicineEndocrinologyInsulin resistanceProinflammatory cytokineHypothalamusMedicineInsulinHormoneInflammationAdipokine
- Has abstract in OpenAlex
- yes