DNA-Passivated CdS Nanocrystals: Luminescence, Bioimaging, and Toxicity Profiles
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
A class of luminescent semiconductor quantum dots is described that exhibit low cellular toxicity without the use of bulky surface coatings. Nucleic acids, either in the form of mononucleotides or DNA oligonucleotides, are used as a ligand system in the aqueous synthesis of CdS nanocrystals. The materials produced exhibit diameters on the order of 4 nm and luminescence in the range of 500-700 nm. Importantly, DNA-CdS is stable in buffers of high ionic strength for many hours. When tested for toxicity in HeLa cells, minimal decreases in cell viability were observed, indicating that the DNA-CdS nanocrystals are highly stable in biological media. Uptake of the nanocrystals into unfixed mammalian cells was tested, and internalization was observed. The results reported indicate that the use of DNA as a ligand system for water-soluble semiconductor nanocrystals represents a worthwhile strategy for the production of new biological imaging agents.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it