P114Role of atrial remodeling in reentrant dynamics during in-vitro atrial fibrillation
Bibliographic record
Abstract
Introduction: The role of tissue remodeling in the reentrant activity during atrial fibrillation (AF) is not well understood. The aim of this study is to evaluate in an in-vitro model of AF the role of tissue remodeling in the mechanisms of perpetuation of this arrhythmia. Methods: HL-1 cultures were obtained for early stage (6.1 ± 1.3 days in culture, N=10) and late stage (11.7 ± 0.5 days in culture, N=8) AF. Bright field images together with optical calcium mapping (Rhod-2AM staining) were obtained for evaluating remodeling and electrophysiological characteristics of cell cultures. Results: The number of singularity points per square centimeter at baseline was significantly higher in the late stage group (i.e. 0.43±0.19 vs. 1.12±0.14 PS/cm2, p <0.01) and showed an inverse correlation with the degree of homogeneity in the corresponding bright field microscopy images (R2=0.78, p <0.01) (Fig.1). These results demonstrate that the electrical complexity in the dish increased with the culture time. Rotor dynamics (i.e. curvature and rotor movement) were significantly correlated with the amount of PSs in the cultures (R2=0.86 and R2=0.79 respectively, Fig. 1). Figure 1
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".