Electron Microscopy of Human Platelet Aggregates Formed in vitro with and without Fibrin Production
Bibliographic record
Abstract
The morphology of groups of platelets aggregated by means of an extract of the venom of the snake Trimeresurus okinavensis was contrasted with the appearances which occur when platelets aggregate to form an artificial thrombus in Chandler’s apparatus. The adhesion of platelets induced by venom extract illustrated many of the features usually seen at an early stage in the aggregation of platelets in plasma except for the absence of the formation of fibrin. The form and content of platelet profiles within the aggregates were readily distinguishable. Two platelet aggregates, one containing 43 profiles and the other 123 profiles, each typical of a type of aggregate, were taken for close study. The majority of platelet profiles in section which were greater in size than 1 µm2 contained granules and in general those that were smaller than this did not. No granules were seen external to the aggregates. It is suggested that granule-free profiles of platelets represent peripheral processes from a granule-rich core cytoplasm and that as such these platelets are not ‘degranulated’.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".