Boosting intermediate-term into long-term memory
Bibliographic record
Abstract
Aerial respiration in the pond snail Lymnaea stagnalis can be operantly conditioned. Depending on the specific training procedure used (i.e. a 0.5 h vs a 1.0 h interval between training sessions) either intermediate (ITM) or long-term memory (LTM) is formed. ITM, which persists for 2-3 h, is dependent only on de novo protein synthesis, whilst LTM persists for up to 4 weeks and is dependent on both transcription and de novo protein synthesis. We found that although the behavioural phenotype of ITM was not apparent 24 h after the last training session, a residual memory trace was present that serves as a foundation upon which a subsequent ITM-training-procedure builds on to form LTM (i.e. a "changed memory"). This residual memory trace could be perturbed by cooling, the behavioural process of context-specific extinction and by increasing the interval between the training procedures. Furthermore in preparations where the somata of RPeD1 (one of three interneurons in the central pattern generator required for aerial respiratory behavior) had been ablated before training, LTM could not be observed following a second bout of ITM-training. These data support the concept that a molecular memory trace is established as a consequence of ITM-training, which serves as a "permissive substrate", when the ITM memory is made active, sufficient to permit the necessary transcription and translation processes that are causal for LTM formation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".