Saccharin- or Quinine-Induced Changes in the Rat Pups following Prolonged Ingestion by the Dam
Bibliographic record
Abstract
Effects presumably induced by a chronic free ingestion of saccharin (0.40 mg/ml) or of quinine (0.25 mg/ml) by female rats during the pregestative, gestative and lactating periods were investigated in the ensuing progeny. Preweaned pups were studied from birth up to weaning (21 days of age) by means of selected gross behavioral tests. The saccharin litters were mainly characterized by a slowering in the body growth evolution. The quinine pups demonstrate several physical anomalies: (1) congenital malformations in 5% of the animals; (2) a significantly reduced birth weight followed by a persistent growth retardation, and (3) a significant delay in the teeth eruption (1.6 and 2.6 days) and in the eye openings (1.6 days). In comparison to the untreated offspring, the saccharin pups showed minor effects whereas quinine-exposed rats were clearly impaired in several features of the postnatal physical development. Therefore, the addition of the sweetener to morphine solution may be convenient for the voluntary oral consumption of the narcotic. Conversely, quinine, used to habituate animals to drinking bitter solutions, has to be rejected in this narcotization procedure as being a harmful agent to the growing rat.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".