IC‐P‐069: Cerebral ventricular subvolume analysis from MRI: A marker of Alzheimer's disease progression validated using ADNI
Bibliographic record
Abstract
Cerebral ventricular volume measured from magnetic resonance images (MRI) is an indirect global marker of Alzheimer disease (AD) progression. Quantification of ventricular sub-regions may allow characterization of topographical disease progression and may also detect regional differences between normal elderly controls (NEC), subjects with mild cognitive impairment (MCI) and AD in vivo. Objectives: To evaluate ventricle sub-region volume and enlargement between NEC, MCI, and AD groups. Baseline and 12-month clinical and MRI data were obtained for 511 subjects (NEC = 106;MCI = 261;AD = 124) from the Alzheimer Disease Neuroimaging Initiative database. Ventricular volume sub-region analysis was performed using Brain Ventricle Quantification (BVQ) (Cedara Software). BVQ parcellates the ventricles into 10 anatomical regions using highly reproducible anatomical rules. One-way ANOVA and Student-Newman-Keuls tests were used for group-wise comparisons. All volumes are reported as mean ± SD. Baseline total (NEC = 1.5 ± 1.0 cm; MCI = 2.2 ± 1.5 cm; AD = 3.0 ± 2.0 cm) and bilateral temporal horn volumes were significantly different between all three groups (p < 0.01). Total anterior horn volumes were greater for both the MCI (12.6 ± 7.6 cm) and AD groups (13.8 ± 8.4 cm) in comparison to NEC (11.0 ± 6.8 cm)(p < 0.01). The AD group had a significantly greater total mid-body volume (14.9 ± 7.0 cm) than the MCI (13.4 ± 6.3 cm) and NEC groups (12.3 ± 5.7 cm)(p < 0.01). All groups had significantly different total posterior horn volumes (NEC = 16.4 ± 9.6 cm; MCI = 20.5 ± 12.7 cm; AD = 24.3 ± 15.0 cm)(p < 0.01). Bilateral temporal horn enlargement was significantly greater for the AD group (0.3 ± 0.3 cm) than the MCI (0.2 ± 0.2 cm) and NEC groups (0.1 ± 0.2 cm)(p < 0.01). Subjects with MCI had a greater average right temporal horn enlargement than NEC subjects (p < 0.01). Baseline volume and enlargement within the bilateral posterior cornus and temporal horns suggests marked atrophy occurs around the medial temporal lobe in MCI, and to a greater extent in AD in comparison to NEC. Persons with MCI had larger anterior horns than NEC, suggesting frontal lobe atrophy may occur in MCI. Cross-sectional and longitudinal measures of ventricular sub-regions reflect the topographical progression of AD in vivo.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".