Effect of Magnesium Diet in Gentamicin-Induced Acute Renal Failure in Rats
Bibliographic record
Abstract
Clearance experiments were conducted with metabolic cages to determine the effect of dietary magnesium on gentamicin nephrotoxicity. Three groups of male Wistar rats were given low, medium- or high-magnesium diets. Following baseline clearances, gentamicin was administered by intramuscular injection (20 mg/kg). Additional clearances were performed 6 and 11 days after gentamicin administration. 24-hour clearances were also taken 8 days after gentamicin withdrawal. The present experiments demonstrated that high magnesium intake protected the kidney against injury induced by gentamicin. This reduction in nephrotoxicity was probably due to competition of binding between magnesium and gentamicin to the renal membrane. Histological examinations were also done in these animals. The results showed that the most severe changes were seen in rats receiving a low-magnesium diet. Rats given a high-magnesium diet showed the least toxic changes while rats receiving a medium-magnesium diet showed changes of intermediate severity. These observations complemented the results obtained from 24-hour clearances and indicate the protective effect of dietary magnesium on the development of acute renal failure following administration of gentamicin.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".