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Record W2018991353 · doi:10.1126/science.1194167

Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate

2010· article· en· W2018991353 on OpenAlexaff
France Denœud, Simon Henriet, Sutada Mungpakdee, Jean‐Marc Aury, Corinne Da Silva, Henner Brinkmann, Yana Mikhaleva, Lisbeth C. Olsen, Claire Jubin, Cristian Cañestro, Jean‐Marie Bouquet, Gemma Danks, Julie Poulain, Coen Campsteijn, Marcin Adamski, Ismael Cross, Fekadu Yadetie, Matthieu Muffato, Alexandra Louis, Stephen Butcher, Georgia Tsagkogeorga, Anke Konrad, Sarabdeep Singh, Marit Flo Jensen, Evelyne Huynh Cong, Helen Eikeseth-Otteraa, Benjamin Noël, Véronique Anthouard, Betina M. Porcel, Rym Kachouri‐Lafond, Atsuo Nishino, Matteo Ugolini, Pascal Chourrout, Hiroki Nishida, Rein Aasland, Snehalata Huzurbazar, Éric Westhof, Frédéric Delsuc, Hans Lehrach, Richard Reinhardt, Jean Weissenbach, Scott William Roy, François Artiguenave, John H. Postlethwait, J. Robert Manak, Eric M. Thompson, Olivier Jaillon, Louis Du Pasquier, Pierre Boudinot, David A. Liberles, Jean‐Nicolas Volff, Hervé Philippe, Boris Lenhard, Hugues Roest Crollius, Patrick Wincker, Daniel Chourrout

Bibliographic record

VenueScience · 2010
Typearticle
Languageen
FieldEnvironmental Science
TopicMarine Ecology and Invasive Species
Canadian institutionsUniversité de Montréal
FundersNational Institutes of Health
KeywordsBiologyChordateGenomeEvolutionary biologyTunicateLineage (genetic)Pelagic zonePhylogeneticsGeneGeneticsEcology

Abstract

fetched live from OpenAlex

Ocean Dweller Sequenced The Tunicates, which include the solitary free-swimming larvaceans that are a major pelagic component of our oceans, are a basal lineage of the chordates. In order to investigate the major evolutionary transition represented by these organisms, Denoeud et al. (p. 1381 , published online 18 November) sequenced the genome of Oikopleura dioica , a chordate placed by phylogeny between vertebrates and amphioxus. Surprisingly, the genome showed little conservation in genome architecture when compared to the genomes of other animals. Furthermore, this highly compacted genome contained intron gains and losses, as well as species-specific gene duplications and losses that may be associated with development. Thus, contrary to popular belief, global similarities of genome architecture from sponges to humans are not essential for the preservation of ancestral morphologies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.199
Teacher spread0.194 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations304
Published2010
Admission routes1
Has abstractyes

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