Sound‐guided shaping of the receptive field in the mouse auditory cortex by basal forebrain activation
Bibliographic record
Abstract
The mammalian auditory cortex undergoes continuous plasticity following auditory experience. This study demonstrates the instructive roles of sound frequency and amplitude in representational plasticity in the primary auditory cortex of the mouse. Electrical stimulation of the basal forebrain paired with a tone led to a pronounced shift in the receptive field of the cortical neurons in both frequency and amplitude domains, the shift being towards the frequency and amplitude of the tone. Importantly, the plasticity in the frequency tuning of cortical neurons appeared to be largely dependent upon frequency-specific decreases in the response threshold. The minimum threshold of cortical neurons could be reduced only if the amplitude of the presented tone was lower than the minimum threshold. This finding suggests that training with low-intensity sound can increase the sensitivity of cortical neurons. Furthermore, all of these effects evoked by basal forebrain activation could be eliminated by cortical application of atropine, the acetylcholine muscarinic receptor antagonist. The data suggest that cortical plasticity is guided by both sound frequency and amplitude. The basal forebrain promotes sound-guided cortical plasticity by facilitating neural mechanisms intrinsic to the auditory system.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".