Canadian Experience With Implementation of an Acellular Pertussis Vaccine Booster-Dose Program in Adolescents: Implications for the United States
Bibliographic record
Abstract
BACKGROUND: In Canada, the epidemiology of pertussis has changed during the past decade such that more cases occur in adolescents than in any other age cohort. METHODS: The implications of the Canadian experience, as well as the experiences of France, Germany, and Australia, on the universal implementation of an acellular pertussis, diphtheria, and tetanus booster vaccine in the United States are discussed. RESULTS: In 1999, an acellular pertussis vaccine combined with diphtheria and tetanus toxoids formulated for adolescents and adults was licensed for use in Canada. It has taken >5 years for this vaccine to be introduced universally into the immunization programs of all provinces and territories. The delay in implementation has likely been the result of insufficient epidemiologic data available to the National Advisory Committee on Immunization and the lack of a consensus on the appropriate goals of the national pertussis control strategy. Implementation of an immunization program in all parts of the country occurred only after a national consensus was achieved and federal funding was made available for vaccine purchase. CONCLUSIONS: The Canadian experience demonstrates that an adolescent pertussis vaccine program can be implemented on a national scale after several factors have been considered.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".