Effect of Sulphaphenazole on Pathogenic Microorganism Klebsiella aerogenes
Bibliographic record
Abstract
The inhibitory action of Sulphaphenazole on pure culture of Klebsiella aerogenes was studied with emphasis onthe mode of action of the drug. Sensitivity was studied by broth dilution method and by Hi-Comb Method. TheMinimum Inhibitory Concentration (MIC) of Sulphaphenazole determined by broth dilution method andHi-Comb Method against Klebsiella aerogenes was 30 ?g/ml. Sulphaphenazole induced changes in bacteriawhich interfered with cell wall synthesis revealing morphological alterations that was shown by ScanningElectron Microscopy (SEM). The present studies were undertaken to investigate the presence and characteristicalterations in surface morphology of cells resulting from the action of Sulphaphenazole known to interfere withintracellular protein synthesis. The morphological abnormalities observed may be surface reflections of specificabnormalities of intracellular protein synthesis or may represent a final common pathway of drug-induced injuryat many sites within or on bacterial cells. As the activity of dehydrogenases was inhibited by Sulphaphenazole,cells were incapable of oxidizing substrate. It resulted in limited supply of energy rich compounds such as ATPthat affected the synthesis of macromolecules. Ultimately multiplication and growth of the organism got ceased.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".