Comparison of chromosomal behavior in cultured lymphocytes and fibroblasts from patients with chromosomal disorders and controls
Bibliographic record
Abstract
The occurrence of satellite association, breaks, tetraploidy or endoreduplication, and structural rearrangements was studied and compared in 600 lymphocyte and 600 skin-fibroblast metaphases from 30 karyotypically normal individuals and in 820 lymphocyte and 820 skin-fibroblast metaphases from 41 patients with various chromosomal disorders. The frequency of satellite association was less (0.02 < P < 0.05) in fibroblast than lymphocyte cultures of both the control and abnormal groups. The incidence of breaks in the controls was 2.5 % in lymphocytes and 4.2% in cultured fibroblasts. In patients with chromosomal disorders, the incidence was 5.5% in cultured lymphocytes and significantly greater (P < 0.01), 15.2%, in cultured fibroblasts. The incidence of tetraploid cells (including endoreduplication) in lymphocyte cultures was 0.2% of 3000 cells in the controls and 0.3% of 4100 cells in the abnormal group; this was significantly less (P < 0.01) than the incidence in fibroblast cultures, 3.9% of 3000 control cells and 3.7% of 4100 cells in the abnormal group. The excess of breaks and tetraploid cells in cultured fibroblasts compared to cultured lymphocytes may be due to the longer duration in culture, with increased risk of chromosomal damage, of the fibroblast cultures.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".