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Record W2022124811 · doi:10.1242/jeb.109686

Mitochondria fail before hearts in hot wrasse

2014· article· en· W2022124811 on OpenAlexaboutno aff
Kathryn Knight

Bibliographic record

VenueJournal of Experimental Biology · 2014
Typearticle
Languageen
FieldEnvironmental Science
TopicPhysiological and biochemical adaptations
Canadian institutionsnot available
Fundersnot available
KeywordsEctothermWrasseTemperate climateBiologyEcologyZoologyMitochondrionFisheryFish <Actinopterygii>Cell biology

Abstract

fetched live from OpenAlex

For those of us that are insulated from the vagaries of the climate by our ability to generate our own warmth, it can be hard to understand the physiological challenges faced by ectothermic animals, which depend on their surroundings to maintain their body temperature. And for aquatic ectotherms that are used to a specific range of comfortable temperatures, the challenges might just be about to get more serious. Tony Hickey from the University of Auckland, New Zealand, explains that as temperatures rise, fish are at risk of heart failure and it was thought that the failure of the mitochondria that power muscle contraction might contribute. Hickey and his colleague Fathima Iftikar teamed up with researchers from Australia and Canada to compare how the hearts and the energy-generating mitochondria of three species of wrasse that inhabit different environments (tropical, temperate and cold temperate) cope in warmer waters (p. 2348). Gently increasing the temperature of the fish's water, Iftikar monitored the fish's heart rates and found that the tropical species (Thalassoma lunare) – which inhabits the narrowest thermal range – was most impacted by a rise in temperature. The power-producing mitochondria also began to fail before all three species experienced full heart failure as the temperature rose. In addition, she found that the fish's mitochondria were impacted at different points in the energy-generation process, indicating that the mechanism of mitochondrial failure was different in each species. Suggesting that temperature limitations on mitochondrial function might restrict the thermal ranges that wrasse occupy, the team concludes by saying, ‘Understanding mitochondrial function, or dysfunction, in ectotherms such as fish still requires study… to better understand the potential ramifications of climate change.’

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.264
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes1
Has abstractyes

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