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Neuropsychologic and neuropsychiatric characteristics of patients withFriedreich's ataxia

2000· article· en· W2022177952 on OpenAlex
M. White, R. Lalonde and, Thérèse Botez-Marquard

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueActa Neurologica Scandinavica · 2000
Typearticle
Languageen
FieldNeuroscience
TopicGenetic Neurodegenerative Diseases
Canadian institutionsHôtel-Dieu de MontréalHôtel-Dieu de QuébecCentre hospitalier universitaire de Québec
Fundersnot available
KeywordsAtaxiaStroop effectPsychologyAudiologyVerbal fluency testMoodPrefrontal cortexExecutive functionsFrontal lobeNeuropsychologyMood disordersPsychiatryCognitionMedicineAnxiety

Abstract

fetched live from OpenAlex

UNLABELLED: OBJECTIVES AND MATERIALS AND METHODS: Due to recent evidence of frontal-lobe related dysfunctions in patients with cerebellar atrophy, patients with Friedreich's ataxia were compared to normal subjects controlled for age, gender, and educational level on tests measuring information processing speed, visuospatial organization, selective attention, executive functions, and mood. RESULTS: Patients with Friedreich's ataxia had slowed information speed, as indicated by lengthened simple visual reaction time and increased color-word interference in the Stroop task. However, the patient group was not impaired in several tests sensitive to neocortical and particularly prefrontal cortex lesions, including an untimed version of block design, verbal fluency, Wisconsin card sorting, Tower of Hanoi, and picture arrangement. Despite serious sensorimotor dysfunctions, the patient group did not differ from controls in terms of mood, as evaluated by the Symptoms Checklist (SCL-90) and the Hamilton depression scale. CONCLUSION: These results indicate that the slowed information processing speed of patients with Friedreich's ataxia is not accompanied by major prefrontal cortex and mood disorders.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.324
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.236
Teacher spread0.222 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it