MétaCan
Menu
Back to cohort
Record W2022258486 · doi:10.1164/rccm.200401-098oe

A Century of the Mechanics of Breathing

2004· article· en· W2022258486 on OpenAlexaff
Peter T. Macklem

Bibliographic record

VenueAmerican Journal of Respiratory and Critical Care Medicine · 2004
Typearticle
Languageen
FieldMedicine
TopicInhalation and Respiratory Drug Delivery
Canadian institutionsMcGill UniversityMcGill University Health Centre
Fundersnot available
KeywordsTranspulmonary pressureExpirationMedicineRespiratory physiologyMechanicsWork (physics)Work of breathingSurface tensionIntensive care medicineMechanical engineeringLung volumesLungRespiratory systemMechanical ventilationPhysicsEngineeringThermodynamicsAnesthesia

Abstract

fetched live from OpenAlex

When the twentieth century began, a substantial amount was already known about the mechanics of breathing, and the respiratory muscles. The chest wall had been modeled as a bellows with a bladder inside representing the lung. It was known that the respiratory system was elastic and stored energy on inflation that did the work of expiration. Measurements of transpulmonary pressure had been made and there had been attempts to correlate these with lung volume (1). However, a century ago we had no framework in which to view measurements. Without a model of how the system behaves, measurements of respiratory mechanics are uninterpretable. In addition, we lacked technology to make measurements. In the past 100 years this has changed: modeling has provided great insights into the system’s behavior and technological advances have permitted measurements that previously were impossible. Sometimes, however, advances are made without new models and new technology because scientists view problems from new perspectives. Such appears to be the case with surface tension, which I discuss separately. This review is not comprehensive, but focuses on the role of models and technology in the development of new knowledge in the field and on discoveries related to surface tension. Only a limited number of topics are discussed. I apologize to those whose work should be included, but that I fail to discuss. MODELING Lung Models

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.465
Threshold uncertainty score0.381

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.294
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2004
Admission routes1
Has abstractyes

Explore more

Same venueAmerican Journal of Respiratory and Critical Care MedicineSame topicInhalation and Respiratory Drug DeliveryFrench-language works237,207