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Record W2022258486 · doi:10.1164/rccm.200401-098oe

A Century of the Mechanics of Breathing

2004· article· en· W2022258486 on OpenAlexaff
Peter T. Macklem

Bibliographic record

VenueAmerican Journal of Respiratory and Critical Care Medicine · 2004
Typearticle
Languageen
FieldMedicine
TopicInhalation and Respiratory Drug Delivery
Canadian institutionsMcGill UniversityMcGill University Health Centre
Fundersnot available
KeywordsTranspulmonary pressureExpirationMedicineRespiratory physiologyMechanicsWork (physics)Work of breathingSurface tensionIntensive care medicineMechanical engineeringLung volumesLungRespiratory systemMechanical ventilationPhysicsEngineeringThermodynamicsAnesthesia

Abstract

fetched live from OpenAlex

When the twentieth century began, a substantial amount was already known about the mechanics of breathing, and the respiratory muscles. The chest wall had been modeled as a bellows with a bladder inside representing the lung. It was known that the respiratory system was elastic and stored energy on inflation that did the work of expiration. Measurements of transpulmonary pressure had been made and there had been attempts to correlate these with lung volume (1). However, a century ago we had no framework in which to view measurements. Without a model of how the system behaves, measurements of respiratory mechanics are uninterpretable. In addition, we lacked technology to make measurements. In the past 100 years this has changed: modeling has provided great insights into the system’s behavior and technological advances have permitted measurements that previously were impossible. Sometimes, however, advances are made without new models and new technology because scientists view problems from new perspectives. Such appears to be the case with surface tension, which I discuss separately. This review is not comprehensive, but focuses on the role of models and technology in the development of new knowledge in the field and on discoveries related to surface tension. Only a limited number of topics are discussed. I apologize to those whose work should be included, but that I fail to discuss. MODELING Lung Models

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.009
Threshold uncertainty score0.031

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.004
Scholarly communication0.0030.005
Open science0.0010.003
Research integrity0.0030.005
Insufficient payload (model declined to judge)0.0090.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.294
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2004
Admission routes1
Has abstractyes

Explore more

Same venueAmerican Journal of Respiratory and Critical Care MedicineSame topicInhalation and Respiratory Drug DeliveryFrench-language works237,207