Correlation of parasitological and immunological parameters in sheep with high and low resistance to haemonchosis
Bibliographic record
Abstract
Parasitological and immunological parameters of Blackbelly (Bb), a haemonchosis high-resistance sheep breed, and Columbia (Cb) a haemonchosis low-resistance breed were compared. Two experiments were performed: Bb and Cb lambs were infected weekly with 1000 third-stage larvae (L3) of Haemonchus contortus for 6 wk. In the first experiment, faecal egg counts (FEC) and blood eosinophils (BE) were determined for 15 wk. In the second experiment, the following parameters were measured weekly: FEC, plasma proteins, serum IgG to H. contortus L3 levels by ELISA and L3 antigens recognized by Western blot; animals were euthanized after 15 weeks and autopsies were performed to evaluate the total adult phases (AP), eosinophils and mast cells in the fundic abomasal region (FAR), pyloric abomasal region (PAR) and abomasal lymph node (ALN). Fecal egg counts and AP were significantly higher (P < 0.05) in Cb lambs. BE showed a significant increase (P < 0.05) in both breeds at week 9 and, subsequently, Cb lambs presented a sudden decrease in these levels. The Bb lambs revealed a higher amount (P < 0.05) of antibodies between weeks 9 and 15 of the experiment, and Cb lambs showed a reduction in antibody levels at week 9. The Western blot revealed 11 bands of H. contortus L3 antigens; no differences were observed between breeds. The number of tissue eosinophils per cm 2 in PAR and ALN was higher (P < 0.05) in the Bb lambs. No differences were found (P > 0.05) in the number of mast cells per cm 2 in the sampled regions of both infected groups. The increase and maintenance of serum antibodies and circulating and local eosinophils in resistant animals agrees with the development and maintenance of a Th 2 type immune response. The initial increase and further reduction of serum antibodies and circulating and local eosinophils in the low-resistance lamb breed suggest an initial Th 2 type response and a subsequent change to a Th 1 type response. Key words: Haemonchus, immune response, breed resistence, eosinophils, antibodies, sheep
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".