Nitrofurantoin-Induced Pulmonary Reaction Involving Respiratory Symptoms: Case Report
Bibliographic record
Abstract
1Early recognition of such reactions may prevent disability and death. 2 This article describes a patient with an acute pulmonary reaction, specifically bronchiolitis obliterans organizing pneumonia (BOOP), which occurred after exposure to nitrofurantoin. The patient required intubation, and the condition was responsive to withdrawal of the drug followed by steroid therapy. CASE REPORT An 82-year-old man presented with worsening shortness of breath and nonproductive cough of new onset over the previous 6 days.* He had no other symptoms of an upper respiratory infection. His medical history was significant for mild cognitive impairment, gastroesophageal reflux, benign prostatic hyperplasia requiring transurethral prostatic repair, and remote cholecystectomy. Cystitis had been diagnosed 15 days before admission and was initially treated with trimethoprim 100 mg twice daily. Five days later, he was switched to nitrofurantoin 100 mg twice daily because of lack of improvement with the original drug. After the first 7-day course of nitrofurantoin therapy, the patient immediately began a second course of nitro furantoin with a projected duration of 7 days. The patient presented to hospital 4 days after starting the second course (i.e., 11 days after initiation of nitrofurantoin therapy). He reported
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.004 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.004 | 0.002 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.008 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".