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Record W2023271893 · doi:10.1051/medsci/2013294007

Une avancée technique pour comprendre la dynamique de l’horloge de segmentation

2013· article· fr· W2023271893 on OpenAlexaff
Emilie Delaune, Paul François, Nathan P. Shih, Sharon L. Amacher

Bibliographic record

Venuemédecine/sciences · 2013
Typearticle
Languagefr
FieldBiochemistry, Genetics and Molecular Biology
TopicPluripotent Stem Cells Research
Canadian institutionsMcGill University
Fundersnot available
KeywordsInduced pluripotent stem cellNeural stem cellReprogrammingNeurogenesisBiologyHumanitiesStem cellNeuroscienceEmbryonic stem cellCell biologyPhilosophyCellGenetics

Abstract

fetched live from OpenAlex

355 10. Winner B, Melrose HL, Zhao C, et al. Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiol Dis 2011 ; 41 : 706-16. 11. Coulombel L. Reprogrammation nucleaire d’une cellule differenciee : on efface tout et on recommence. Med Sci (Paris) 2007 ; 23 : 667–70. 12. Maury Y, Gauthier M, Peschanski M, Martinat C. Human pluripotent stem cells: opening key for pathological modeling. Med Sci (Paris) 2011 ; 27 : 443-6. 13. Laustriat D, Gide J, Hechard C, Peschanski M. Les cellules souches embryonnaires et le pharmacologue. Med Sci (Paris) 2009 ; 25 (suppl 2) : 32-8. 5. Tiscornia G, Vivas EL, Izpisua Belmonte JC. Diseases in a dish: modeling human genetic disorders using induced pluripotent cells. Nat Med 2011 ; 17 : 1570-6. 6. Papp B, Plath K. Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape. Cell Res 2011 ; 21 : 486-501. 7. Liu GH, Barkho BZ, Ruiz S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 2011 ; 472 : 221-5. 8. Marchetto MC, Carromeu C, Acab A, et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010 ; 143 : 527-39. 9. Liu GH, Qu J, Suzuki K, et al. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 2012 ; 491 : 603-7. REFERENCES

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.169
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.305
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2013
Admission routes1
Has abstractyes

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