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Record W2023368645 · doi:10.1055/s-2009-1216428

Recent Developments in Regulatory Matters on Herbal Medicinal Products in Europe

2009· article· en· W2023368645 on OpenAlexfundno aff
A Vlietinck

Bibliographic record

VenuePlanta Medica · 2009
Typearticle
Languageen
FieldMedicine
TopicPhytochemical and Pharmacological Studies
Canadian institutionsnot available
FundersNational Institute on Drug AbuseAgricultural Research ServiceUniversity of British ColumbiaUniversity of Illinois at Urbana-ChampaignChinese Academy of SciencesKurukshetra UniversityUniversity of Illinois at ChicagoNational Oceanic and Atmospheric AdministrationU.S. Food and Drug AdministrationNational Science Foundation of Sri LankaUniversity of ColomboU.S. Department of AgricultureWestern Carolina UniversityInternational Science CouncilNational Center for Complementary and Alternative MedicineChina Academy of Traditional Chinese MedicineNational Institutes of HealthNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseasesTürkiye Bilimsel ve Teknolojik Araştırma KurumuHong Kong Polytechnic UniversityNational Science FoundationDeutsche KrebshilfeNational Natural Science Foundation of ChinaTata TrustsUniversity Grants CommissionWake Forest University
KeywordsEuropean unionCosmeticsTraditional medicineMedicineDirectiveFood productsBusinessLegislatureMedicinal herbsBiotechnologyPolitical scienceInternational tradeFood scienceLawBiology

Abstract

fetched live from OpenAlex

Within the group of industrially prepared herbal or botanical products there is a large variation worldwide with regard to the properties and the legal status of these products. Some herbal products are close to or are medicines, while others are close to or even identical to foods such as dietary supplements, functional foods, novel foods, etc. and still others are considered as cosmetics or medical devices. Therefore it is not surprising that recently appropriate regulatory actions have been undertaken to regulate and harmonize the legal status of these various groups of plant preparations throughout Western countries. The European Union (EU) has recently considered herbal products in several legislative texts. Medicinal use has been harmonized for herbal medicinal products (HMP) with regard to well-established (WE) and traditional (T) uses through Directives 2004/27/EC and 2004/24/EC amending Directive 2001/83/EC. Use of herbal preparations in unit dose form under food law is covered in the Food Supplements Directive (FSD) 2002/46/EC. Regulations on nutrition and health claims and the addition of vitamins and minerals and certain other substances to foods have been adopted on December 12, 2006. (Council Regulations (EC) n°1924/2006 and 1925/2006). Nevertheless, the distinction between traditional herbal medicinal products and food supplements containing herbal products without nutritional value but having physiological effects remains vague and controversial. In this presentation the implementation of the current European regulations at the level of the EU Member State authorities and manufacturers in terms of quality, safety and efficacy of these herbal products will be discussed. A comparison will be made with other concepts existing worldwide, taking into account not only the above mentioned properties, but also aspects such as access to the market, cost price, and prospects for innovation of herbal products.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.636
Threshold uncertainty score0.404

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.292
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2009
Admission routes1
Has abstractyes

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