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NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2

2000· article· en· 706 citations· W2023887529 on OpenAlex· 10.1053/gast.2000.16510

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Non-randomized trialObservationalBench or experimental
Classifier consensus
ObservationalBench or experimental
Teacher imitation scores

Codex

Bench or experimental0.394
Observational0.095
Other design0.002
Randomized trial0.002
Systematic review0.002
Not applicable0.001
Metaresearch0.001
Case report0.000
Theoretical or conceptual0.000
Simulation or modelling0.000
Research integrity0.000
Non-randomized trial0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Scholarly communication0.000
Open science0.000
Qualitative0.000
Science and technology studies0.000
Meta-analysis0.000

Gemma

Observational0.512
Bench or experimental0.043
Randomized trial0.003
Non-randomized trial0.003
Case report0.001
Not applicable0.001
Simulation or modelling0.001
Systematic review0.000
Research integrity0.000
Meta-analysis0.000
Theoretical or conceptual0.000
Metaresearch0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Science and technology studies0.000
Scholarly communication0.000
Meta-epidemiology (broad)0.000
Qualitative0.000
Open science0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.013
GPT teacher head0.258
Teacher spread
0.245 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

BACKGROUND & AIMS: Selective cyclooxygenase (COX)-2 inhibitors produce less gastric damage than conventional nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that NSAIDs cause damage by inhibiting COX-1. We tested this hypothesis in rats by using a selective COX-1 inhibitor (SC-560).

METHODS

The effects of SC-560, celecoxib (selective COX-2 inhibitor), or a combination of both inhibitors on gastric damage and prostaglandin synthesis were determined. Selectivity of the drugs for COX-1 vs. COX-2 w…

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