Retrograde Axonal Degeneration (“Dieback”) in the Corticospinal Tract after Transection Injury of the Rat Spinal Cord: A Confocal Microscopy Study
Bibliographic record
Abstract
Axonal dieback is a process in which axons in spinal tracts retract away from the initial site of injury. The purpose of this project is to study the dynamics of dieback in corticospinal tract (CST) axons after various time intervals post-injury, to find the optimal spatial-temporal window for regenerative treatment. Rats received transection injuries at the T8 spinal level and were sacrificed at different time periods (1, 2, 4, 8, and 16 weeks). Three weeks prior to sacrifice, DiI crystals were implanted in the sensorimotor cortex and produced excellent CST labeling, and clear delineation of the terminal bulbs of transected axons. With DiI and confocal microscopy, we visualized axons along the entire length of the CST, and quantified the temporal and spatial features of dieback in axons of the CST based on the location of the terminal bulbs. We found that the majority of axons stopped dieing back 4 weeks after injury by which time they were approximately 2.5 mm from the site of injury. However, at 8 and 16 weeks after injury, some terminal bulbs were more than 10 and 19 mm, respectively, from the site of injury.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".