Paediatric acute lymphoblastic leukaemia mimicking Langerhans cell histiocytosis of bone
Bibliographic record
Abstract
A 12-year-old boy presented with a 4-month history of worsening back pain and right hip pain, with limping and weakness following a fall while snowboarding. He had had transient hip pain 3 months previously, without trauma, but it had resolved. Physical examination revealed an abnormal gait, with a pronounced Trendelenburg limp on the right side. Manual motor testing showed weakness in the right hip abductors (Medical Research Council grade 3/5) with an otherwise unremarkable musculoskeletal examination. His full blood count (white cell count 5·6 × 109/l, platelet count 241 × 109/l and haemoglobin concentration 138 g/l) and blood film were normal. The erythrocyte sedimentation rate was elevated at 20 mm/h and his serum chemistry was normal. An abdominal ultrasound and a chest X-ray were normal, but a skeletal survey showed profound osteopenia with multiple ‘punched out’ lesions in the skull (left), pelvis (middle), proximal femora, tibia and scapula with multiple vertebral compression fractures. These findings were suspicious for Langerhans cell histiocytosis. Magnetic resonance imaging of his pelvis (right) showed diffuse bilateral signal abnormalities involving the femora and pelvis, with patchy oedema and enhancement in the femoral heads. A bone marrow aspirate showed 44% blasts, which, upon immunophenotyping, expressed B-lineage markers CD10, CD19 and CD22; bone marrow biopsy showed positivity for cytoplasmic CD79a. The diagnosis of precursor B acute lymphoblastic leukaemia was confirmed. The presence of large punched out lesions in the skeleton is expected in Langerhans histiocytosis of bone but is an unexpected finding in acute lymphoblastic leukaemia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".