Design and evaluation of an external high‐current target for production of <sup>211</sup>At
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
This report presents the design and testing of an external target system for clinical‐scale production of 211 At on the Scanditronix MC‐50 cyclotron at the University of Washington Medical Center. While other 211 At production sites have typically employed an internal target, an external target setup was deemed necessary at our facility since the cyclotron's main application is for cancer patient treatment via fast neutron therapy. The challenge was that previous external 211 At targets demonstrated reduced yields when compared to internal target systems. The target developed in this study has been used in more than 100 irradiations. From those irradiations 211 At saturated yields of 181 ± 16 MBq/μA and 241 ± 17 MBq/μA at 28.0 and 29.0 MeV, respectively, were obtained. Importantly, consistent yields were observed over the 25–60 μA range of irradiation currents evaluated. With a recent production in excess of 4 GBq 211 At for a 29.0 MeV, 58 μA, 4‐hour irradiation, this external target system has demonstrated its potential for producing clinically relevant quantities of 211 At.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it