Inflammatory bowel disease and spondylarthropathy
Bibliographic record
Abstract
The link between gastrointestinal (GI) function and overall health has been documented throughout history (1,2). It is most clearly illustrated by the inflammatory bowel diseases (IBDs) ulcerative colitis and Crohn’s disease. These are associated with both peripheral and axial arthropathies and are therefore sometimes classified within the group of spondylarthropathies (SpA), classic of which is idiopathic ankylosing spondylitis (AS). SpA usually occurs without overt signs of intestinal inflammation, but the findings of several studies (3–6) have suggested that a significant number of patients with certain forms of SpA may have asymptomatic intestinal inflammation, usually affecting the ileum. Because the pattern of joint disease seen in patients with symptomatic (IBD) and those with asymptomatic (SpA) gut inflammation is similar, it has been suggested that the intestinal inflammation may play a pathogenetic role in the arthritis and secondly that the ileal inflammation in SpA represents a subclinical form of Crohn’s disease. If correct, this suggests an important pathogenetic link between intestinal and joint inflammation. However, elucidating this link is complicated by the fact that most patients with SpA are treated with nonsteroidal antiinflammatory drugs (NSAIDs). This article reviews the clinical and etiologic similarities and differences between IBD and SpA and the possible confounding effects of NSAIDs. Enteric arthritis or arthritic enteritis?
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".