P0325 IMPORTANCE OF HEPATITIS B VIRUS GENOTYPE ON VIRUS REPLICATION
Bibliographic record
Abstract
Introduction: Role of route of transmission on the duration of hepatitis B virus (HBV) infection is well known in children. The aim of our study is to assess the influence of HBV genotypes on HBe Antigen (Ag) loss. Methods: We retrospectively included 115 patients over a 19 year period. Clinical data were: sex, age at diagnosis and at the end-point, route of transmission (vertical or non-vertical), ethnic group, duration of HBS Ag infection and HBe Ag replication, influence of Interferon or Lamivudine therapy. Serological data were HBS Ag and HBe Ag status. After DNA extraction from frozen samples and PCR amplification, we performed genotype identification by Restriction Fragment Length Polymorphism. Results: Our series included 42 boys/73 girls. Contamination was at birth for vertical transmission (n=99) or at 4.5 year-old ± 3.2 SD (1 to 8.5) if non-vertical (n=7). Age at the end-point was 10.7.year-old ± 5.1 SD (0.5 to 21). They were from Asia (n=59), Africa (n=5), Europa (n=16), Canada (n=18), Latin or South America (n=11) and India (n=5). Sixty patients were HBe Ag negative and 5 HBS Ag negative. Eighteen patients were treated with Interferon and 6 with Lamivudine; remission was achieved respectively for 8 and 4 patients. Five genotypes were finded (A-E) within 106 patients, statistically associated with HBe Ag replication (chi2=10.55, p=0.03)(table 1). Kaplan-Meier survival analysis was significant for treatment (p<0.01), limit for genotype (p=0.05), ethnic group (p=0.06), route of transmission (p=0.07), but not significant for sex (p=0.84).Table 1: HBV genotype and HBe Ag statusConclusion: HBV genotype A is predominant within Hbe Ag negative group and genotype B in Hbe Ag positive group. Only treatment influences duration of replication. A larger cohort is needed to assess accurately the effect of genotype, ethnic group and route of transmission on HBV end of replication.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | high |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Bench or experimental | high |
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".