Proteinase‐activated receptors (PARs): An evolving hormonal system
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract An overview of the articles presented in this two‐part special issue of Drug Development Research is provided here. This two‐part series focuses on the discovery, molecular pharmacology, and physiology of the Proteinase‐activated Receptor (PAR) family. This recently discovered G‐protein‐coupled receptor family mediates the signaling properties of a number of serine proteinases, including thrombin. PARs are responsible for a variety of physiological roles that proteinases may now be seen to play in their capacity as “signaling molecules.” It is the aim of the Special Issue articles to illustrate PARs' unique pharmacological properties and to alert the scientific community to the widespread physiological roles this receptor family can play in a variety of settings. Drug Dev. Res. 59:334–335, 2003. © 2003 Wiley‐Liss, Inc.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it