Lung cancer developing in a young patient with Epidermodysplasia verruciformis
Bibliographic record
Abstract
Epidermodysplasia verruciformis (EV) is a rare autosomal recessive hereditary disease, characterized by defects in cell-mediated immunity, susceptibility to skin infections by Human Papillomavirus (HPV) and development of multiple cutaneous sqamouas cell carcinoma. While the oncogenic role of HPV is well recognized, only cutaneous sqamouas cell carcinoma was associated with EV. Herein we report of a patient with EV in whom lung cancer developed at a very young age, raising the possibility that HPV had a causative effect. A 21-year-old man with EV and squamous cell carcinoma of the left lower eyelid was referred to the oncology clinic. One year later, the patient complained of right chest pain. Computer tomography revealed lung mass and a bone lesion. Bone biopsy confirmed the diagnosis of poorly differentiated squamous cell carcinoma of the lung. The cytological features were clearly distinctive from those in the skin. The present case suggests possible association between EV and squamous cell carcinoma of the lung. This observation may contribute to the understanding of the pathogenesis of these conditions.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".