Tyrocidine a from a haliclona sponge derived Vibrio sp
Bibliographic record
Abstract
Taxonomically diverse, sponge-associated microbial communities represent a rich source of potentially novel and bioactive natural products. In our search for bioactive compounds from sponge-associated microbes we isolated and identified a Vibrio sp. from a sample of Haliclona collected from Milne Bay, Papua New Guinea. The Vibrio strain was selected for further investigation on the basis of testing positive for the presence of non-ribosomal peptide synthetase (NRPS) coding genes in our PCR-based screen. Chemical investigation of this Vibrio sp. resulted in the isolation and identification of the NRPS product tyrocidine A, and its decapeptide structure was confirmed by 1D and 2D NMR. Tyrocidine A displayed moderate activity against methicillin resistant S. aureus , E. coli and P. aeruginosa. The discovery of tyrocidine A from a marine Vibrio sp is intriguing from a microbiological viewpoint as it has long been known to be a product of the Gram-positive, soil-dwelling and spore forming Bacillus spp. Aspects of this, and the notion that the marine environment is a largely untapped source of bioactive natural products will be presented.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".