In vitro Clearance and Hemocompatibility Assessment of Ultrathin Nanoporous Silicon Membranes for Hemodialysis Applications Using Human Whole Blood
Why this work is in the frame
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Bibliographic record
Abstract
BACKGROUND/AIMS: Recent advances in nanotechnology have made it possible to mass-produce ultrathin silicon membranes with pore sizes in the range of nanometers. In this study, we investigate the possibility of employing ultrathin nanoporous silicon membranes with pore diameters of 5 and 20 nm for dialysis of human whole blood by performing in vitro clearance and hemocompatibility assessments. METHODS: A mini blood dialyzer is fabricated by mounting nanoporous silicon membranes on a Teflon structure. Clearance is calculated based on the concentration of sodium, chloride, ionized calcium, total CO2, glucose, creatinine and hematocrit measured before and after dialysis. Blood activation is assessed by flow cytometry. RESULTS: Blood contact with the nanoporous membranes induces considerable leukocyte activation. Coating of the membranes with polyethylene glycol significantly improves hemocompatibility without blocking the nanopores. CONCLUSION: Silicon nanoporous membranes are potential candidates for fabrication of miniaturized blood dialyzers. Their mechanical strength and hemocompatibility can be further improved.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it