Suramin inhibits oxidant signalling in tobacco suspension‐cultured cells
Bibliographic record
Abstract
Abstract Plant cells respond to ultraviolet radiation and other oxidant‐generating agents by mobilizing cellular defences, but the signal network linking perception of redox perturbation with defence remains unknown. Irradiation of tobacco suspension‐cultured cells with UVC was found to induce the activation of a specific MAPK 46 (salicylic acid‐induced protein kinase) within 1 min. To explore where UVC and other oxidants might initially act to trigger this signal response, we employed suramin, a non‐membrane‐permeable reagent that interferes with membrane receptor‐mediated signalling in mammalian cells. Pre‐treatment of tobacco cells with suramin strongly attenuated the UVC‐induced activation of MAPK 46 in a concentration‐dependent manner. Suramin was also able to interdict both ozone‐ and hydrogen peroxide‐induced activation of MAPK 46 , indicating that reactive oxygen species (ROS) signalling to the MAPK cascade in general may be initiated at the cell membrane, perhaps through oxidative activation of membrane receptors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".