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Design Issues in a Non-Regulatory Trial

2009· review· en· W2029562441 on OpenAlexaff
Brad Petrisor, Christina L. Goldstein

Bibliographic record

VenueJournal of Long-Term Effects of Medical Implants · 2009
Typereview
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsMcMaster UniversityHamilton Health Sciences
Fundersnot available
KeywordsBlindingRandomized controlled trialRandomizationOrthopedic surgeryMedicineMedical physicsClinical study designPhysical therapyClinical trialSurgeryPathology

Abstract

fetched live from OpenAlex

Randomized, controlled trials (RCTs) represent the highest level of evidence attainable. Although up to 60% of clinical questions cannot be answered by an RCT, it is still the ideal method of comparing orthopedic implants. The strength of the findings of RCTs is a result of the investigator’s ability to limit bias through careful attention to study design. Bias may be limited through randomization, allocation concealment, and blinding. Unfortunately, RCTs involving different surgical techniques or implants present many challenges that may introduce bias and threaten the validity of study results. The purpose of this review is to outline these issues and present possible solutions to these challenges, with the ultimate goal of improving surgeons’ understanding of how to design and critically appraise RCTs involving orthopedic implants.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.721
metaresearch head score (Gemma)0.779
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.279
Threshold uncertainty score0.344

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.7210.779
Meta-epidemiology (narrow)0.0030.004
Meta-epidemiology (broad)0.0120.009
Bibliometrics0.0060.007
Science and technology studies0.0050.023
Scholarly communication0.0160.014
Open science0.0080.006
Research integrity0.0320.019
Insufficient payload (model declined to judge)0.0110.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.326
GPT teacher head0.507
Teacher spread0.182 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2009
Admission routes1
Has abstractyes

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