Alterations in Calcium Transport and Binding by the Plasma Membrane of Mesenteric Arteries from Spontaneously Hypertensive Rats
Bibliographic record
Abstract
The effect of Sr++, Ba++ and Mn++ on calcium uptake by a plasma membrane-enriched fraction from mesenteric arteries of spontaneously hypertensive rats (SHR) was studied to determine what alterations in divalent cation interactions are associated with hypertension. 45Ca++ uptake in the presence of ATP by this fraction from SHR was significantly greater than that of normotensive rats (NWR). This 45Ca++ uptake by these fractions from both types of rat could be reduced by Ba++, Sr++ and nonradioactive Ca++, but not by Mn++; the ability of these cations to compete with 45Ca++ was in the following order Ca++ > Sr++ > Ba++. In contrast, 45Ca++ uptake in the absence of ATP by this subcellular fraction from SHR was significantly less than that of NWR, and this passive 45Ca++ binding could be displaced by Mn++ in addition to the other cations. Both qualitative and quantitative differences were found between SHR and NWR in this study of the effects of cations on calcium uptake by arterial plasma membrane. These results suggest that 1 This investigation was supported by the Alberta Heart Foundation and the Medical Research Council of Canada. 2 In this paper, calcium uptake is used operationally to describe all processes (binding, transport, etc.) leading to calcium accumulation, and calcium transport refers only to the process whereby calcium is transported actively across the vesicle membrane. 3 Dr. Janis was a Fellow of the Canadian Heart Foundation, and his present address is Department of Physiology, Northwestern University Medical School, Chicago, IL 60611 (USA). the plasma membrane of SHR arteries has calcium-binding and -transport properties that are different from those of NWR. However, there is not a complete correlation between the reported effects of the cations on contraction of other arteries in hypertension and on calcium uptake by membranes of SHR and NWR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".