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Record W2030306474 · doi:10.3899/jrheum.090660

Ezetimibe-induced Relapsing Polymyositis: Table 1

2010· letter· en· W2030306474 on OpenAlexvenueno aff
Ignacio García-Valladares, Luis R. Espinoza

Bibliographic record

VenueThe Journal of Rheumatology · 2010
Typeletter
Languageen
FieldMedicine
TopicInflammatory Myopathies and Dermatomyositis
Canadian institutionsnot available
FundersLouisiana State University
KeywordsMedicineEzetimibeMuscle biopsyPrednisoneErythrocyte sedimentation rateInternal medicineAsymptomaticGastroenterologyPolymyositisDeflazacortMyopathyCreatine kinaseCreatinineSurgeryStatinBiopsy

Abstract

fetched live from OpenAlex

The association of statins and myopathy is well established. Much less recognized, however, is the development of muscle involvement following the use of ezetimibe, another lipid-lowering agent introduced recently1–5. We describe a patient with polymyositis (PM) in remission who relapsed after starting therapy with this newer lipid-lowering medication. A 59-year-old African American woman had biopsy-proven PM diagnosed in 2003; she was in complete remission following therapy with tapering doses of prednisone and methotrexate (MTX) for 5 years, and was maintained on weekly oral MTX 15 mg. She was seen on routine followup in September 2008. At that time, she was asymptomatic and performing activities of daily living without difficulties, and had normal muscle strength on examination, and also normal erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum levels of creatinine phosphokinase (CPK) and aldolase. Her history revealed a well controlled hypertension, type II diabetes mellitus, and hypercholesterolemia. She returned a … Address correspondence to Dr. L.R. Espinoza; E-mail: luisrolan{at}msn.com

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.043

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0130.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.244
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2010
Admission routes1
Has abstractyes

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