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Record W2030306474 · doi:10.3899/jrheum.090660

Ezetimibe-induced Relapsing Polymyositis: Table 1

2010· letter· en· W2030306474 on OpenAlexvenueno aff
Ignacio García-Valladares, Luis R. Espinoza

Bibliographic record

VenueThe Journal of Rheumatology · 2010
Typeletter
Languageen
FieldMedicine
TopicInflammatory Myopathies and Dermatomyositis
Canadian institutionsnot available
FundersLouisiana State University
KeywordsMedicineEzetimibeMuscle biopsyPrednisoneErythrocyte sedimentation rateInternal medicineAsymptomaticGastroenterologyPolymyositisDeflazacortMyopathyCreatine kinaseCreatinineSurgeryStatinBiopsy

Abstract

fetched live from OpenAlex

The association of statins and myopathy is well established. Much less recognized, however, is the development of muscle involvement following the use of ezetimibe, another lipid-lowering agent introduced recently1–5. We describe a patient with polymyositis (PM) in remission who relapsed after starting therapy with this newer lipid-lowering medication. A 59-year-old African American woman had biopsy-proven PM diagnosed in 2003; she was in complete remission following therapy with tapering doses of prednisone and methotrexate (MTX) for 5 years, and was maintained on weekly oral MTX 15 mg. She was seen on routine followup in September 2008. At that time, she was asymptomatic and performing activities of daily living without difficulties, and had normal muscle strength on examination, and also normal erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum levels of creatinine phosphokinase (CPK) and aldolase. Her history revealed a well controlled hypertension, type II diabetes mellitus, and hypercholesterolemia. She returned a … Address correspondence to Dr. L.R. Espinoza; E-mail: luisrolan{at}msn.com

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.389
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0020.011
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.244
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2010
Admission routes1
Has abstractyes

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