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Record W2030966444 · doi:10.1371/journal.pmed.1000044

Furious Rabies after an Atypical Exposure

2009· article· en· W2030966444 on OpenAlexaff
Heiman Wertheim, Thai Quoc Nguyen, Kieu Anh Thi Nguyen, M.C.M. de Jong, Walter Taylor, Le Van Tan, Ha Hai Nguyen, Hanh Thuy Nguyen, Jeremy Farrar, Peter Horby, Hien Duc Nguyen

Bibliographic record

VenuePLoS Medicine · 2009
Typearticle
Languageen
FieldImmunology and Microbiology
TopicRabies epidemiology and control
Canadian institutionsInstitute of Infection and Immunity
FundersWellcome Trust
KeywordsRabiesMedicinePost-exposure prophylaxisVirologyEnvironmental health

Abstract

fetched live from OpenAlex

atient 1.A 48-year-old male construction worker, with no preceding medical illnesses, was admitted to the intensive care unit of a hospital in Hanoi.For a few days prior to admission he experienced pain and numbness in both forearms and a flushed sensation throughout his body.He also reported increased perspiration and increased libido.At presentation, the patient was lucid but markedly agitated, and was unable to swallow due to involuntary inspiratory muscle spasms when he was presented with a glass of water (Video S1) or when he felt a breeze.On examination he was afebrile, and had a dry mouth, normal heart rate and blood pressure, and a Glasgow Coma Score of 15.He had no focal neurological signs and no neck stiffness, and Kernig's sign was negative.Neither the patient nor his wife recalled that he had been bitten by a dog, cat, bat, or other mammal in the preceding months, and his skin showed no evidence of recent bite injuries or cuts.Patient 2. A 37-year-old male farmer, without any prior medical history, presented himself to a Hanoi outpatient clinic with increased perspiration, intermittent muscle spasms of both legs, and the inability to drink normally due to involuntary inspiratory muscle spasms when he was presented with a glass of water or felt a breeze.Disease onset was several days before admission.On examination, the patient had a normal body temperature, heart rate, and blood pressure, and a Glasgow Coma Score of 15.The patient was lucid with periods of agitation.There were no focal neurological signs and no neck stiffness, and Kernig's sign was negative.He had bilateral pupil dilatation (~5 mm) with weak direct and consensual light reflexes.There were no signs of recent bites or other skin injuries, but the patient reported that he had been bitten in the heel by a pet dog one month prior to presentation.The dog had remained healthy since the bite.The families of the patients in this manuscript have given written informed consent to publication of their case details.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0020.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.254
Teacher spread0.239 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations71
Published2009
Admission routes1
Has abstractyes

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